Endocrine Abstracts

Introduction: In the literature there are only three papers so far, addressing the impact of thyroid antibodies (Anti-TPO) on pregnancy in Type1 Diabetic Women (DM1) and these present conflicting results. The aim of the study is to evaluate the presence of Anti-TPO in DM1 pregnant women and whether these are related with differences in thyroid function, metabolic control and pregnancy outcome.Methods: In 78 DM1 women with singleton pregnancies Anti-TPO, ...

Introduction: GDM seasonability has been rarely addressed, with conflicting results. The aim of the study is to evaluate monthly GDM incidence in a large group of Greek women.Methods: 7618 pregnant women underwent 100g OGTT during the third trimester (GDM: ADA 2000 criteria). Seasonal, monthly GDM incidences and mean seasonal glucose levels during OGTT were calculated. Mean month temperature data were obtained from the Greek Meteorological Service.<p...

Introduction: Data on the role of endogenous sex steroids in cerebrovascular disease is sparse. Our aim was to investigate the clinical relevance of circulating sex steroids in a postmenopausal acute stroke population and search for associations with disease severity and short-term outcome.Patients and methods: We prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals, during a time period of 2...

Introduction: Several studies have examined the association of the common PvuII polymorphism of the estrogen receptor alpha (ERα) gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease is lacking. We looked for possible associations of the PvuII polymorphism with stroke severity and short-term prognosis in a cohort of female stroke patients.Patients-Methods: We studied 302 postmenopausal ...

Introduction: DHEAS is among the most abundant sex steroid products of the adrenal gland. DHEAS levels have been repeatedly associated with cardiovascular disease, but data concerning cerebrovascular disease, especially in women, is lacking. In this study, we aimed to investigate the role of DHEAS in a female population suffering an acute stroke.Patients and methods: We studied 302 consecutive female patients presenting with an acute stroke hospitalized ...

Impaired estrogen (E2) action is important for cardiovascular disease (CAD) in both men and women. Associations of CAD with estrogen receptor polymorphisms, which may influence sensitivity to E2 have been reported for men but have not been confirmed for women. The aim of the present study was to investigate the association of estrogen receptor common polymorphisms with the severity of coronary disease in women undergoing coronary angiography.Estrogen rec...

Background: Tyrosine Kinase Inhibitors show great promise in the management of metastatic Medullary Thyroid Carcinoma.Somatic mutations are considered to play a major role in the response/resistance to therapies.RET-somatic mutations are present in 45-75% of sporadic MTCs while RAS are rarer.Objectives: The aim of this study is to investigate the mutational profile of 18 spMTC pts, with metastatic/biochemical persistent disease and to look into possible ...